North Carolina - Number and Rate of Fatal Drug Overdose Deaths By Type of Drug in 2021 (CDC)

Updated on February 2, 2026.

According to data from the CDC, the overall number of fatal drug overdose deaths in North Carolina for all drugs was 3,854, and the age adjusted overdose death rate per 100,000 persons was 37.5. The following types of drugs were among the drugs that were involved with high number of overdose deaths: Any Opioids (3,333), Illegally-made Fentanyls (3,025), Any stimulants (2,217), and Cocaine (1,430).

The chart below shows the age-adjusted rate of overdose deaths per 100K by type of drug. The table below shows the number and the overdose death rate by type of drug.

You can see similar information for other states and for the whole United States.

Note: A rate value of 9999 denotes that the value is suppressed. Rates based on less than 20 drug overdose deaths are suppressed to avoid presentation of unstable rates.

Data Source: CDC (SUDORS).
See this for other years:
North Carolina - Age-Adjusted Rate of Fatal Drug Overdose Deaths Per 100K Persons By Type of Drug in 2021
Any Opioids
Illegally-made Fentanyls
Any stimulants
Cocaine
Methamphetamine
Any non-opioid sedatives
Prescription Opioids
Benzodiazepines
Heroin
North Carolina - Number and Rate of Fatal Drug Overdose Deaths By Type of Drug in 2021
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Type of Drug Number of Overdose Deaths Age Adjusted Overdose Death Rate Per 100K
All Drugs 3854 37.5
Any Opioids 3333 32.5
Illegally-made Fentanyls 3025 29.5
Heroin 315 3.1
Prescription Opioids 528 5.2
Any stimulants 2217 21.5
Cocaine 1430 13.8
Methamphetamine 918 9
Any non-opioid sedatives 864 8.4
Benzodiazepines 487 4.8