US Number and Rate of Fatal Drug Overdose Deaths Involving All Drugs By State in 2022 (CDC)

Updated on February 2, 2026.

Based on data from the CDC, the overall number of fatal drug overdose deaths involving All Drugs in the US in 2022 was 58,077, and the age adjusted rate per 100,000 persons was 35. These overall values was based on data from 35 jurisdictions (i.e. states and DC).

Among all states with data, Pennsylvania had the highest number of fatal drug overdose deaths involving All Drugs (5,145), followed by Ohio (5,139), North Carolina (4,087), and Tennessee (3,804).

In terms of the age-adjusted rate of fatal drug overdose deaths involving All Drugs per 100K persons, West Virginia had the highest (82.3), followed by Tennessee (55.5), and Delaware (55.2).

The interactive chart below shows the number of fatal overdose deaths involving All Drugs by state for the jurisdictions with d ata. The table below shows the number and rate of fatal drug overdose deaths.

You can also see similar information for other types of drugs.

Note: A rate value of 9999 denotes that the value is suppressed. Rates based on less than 20 drug overdose deaths are suppressed to avoid presentation of unstable rates.

Related Topics: US CDC Topic List
Data Source: CDC (SUDORS).
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Number of Fatal Drug Overdose Deaths Involving All Drugs By State in 2022 (CDC)
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Number and Rate of Fatal Drug Overdose Deaths Involving All Drugs By State in 2022
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State Number of Deaths Age Adjusted Rate Per 100K
Alaska 256 35.2
Arizona 2603 36.8
Arkansas 537 18.7
Colorado 1663 27.7
Connecticut 1464 40.3
Delaware 537 55.2
Georgia 2587 23.9
Hawaii 249 17.5
Illinois 3565 28.5
Iowa 384 12.8
Kansas 739 26.2
Kentucky 2255 52.2
Maine 683 51.6
Maryland 2534 40.8
Massachusetts 2645 37.7
Minnesota 1313 23.7
Mississippi 661 23.8
Missouri 2035 34.2
Montana 178 16.6
Nebraska 178 9.5
New Hampshire 455 33.2
New Jersey 3127 33.7
New Mexico 933 46.3
North Carolina 4087 39.3
Ohio 5139 45.3
Oklahoma 1301 33.9
Oregon 1292 30.3
Pennsylvania 5145 40.9
Rhode Island 433 39.8
Tennessee 3804 55.5
Utah 580 18.9
Vermont 259 42.8
Virginia 2489 29
West Virginia 1377 82.3
District of Columbia 590 94.5