US Number and Rate of Fatal Drug Overdose Deaths Involving All Drugs By State in 2021 (CDC)

Updated on February 2, 2026.

Based on data from the CDC, the overall number of fatal drug overdose deaths involving All Drugs in the US in 2021 was 51,731, and the age adjusted rate per 100,000 persons was 34.5. These overall values was based on data from 33 jurisdictions (i.e. states and DC).

Among all states with data, Ohio had the highest number of fatal drug overdose deaths involving All Drugs (5,411), followed by Pennsylvania (5,347), North Carolina (3,854), and New Jersey (3,124).

In terms of the age-adjusted rate of fatal drug overdose deaths involving All Drugs per 100K persons, West Virginia had the highest (87), followed by Delaware (53.4), and Kentucky (52.9).

The interactive chart below shows the number of fatal overdose deaths involving All Drugs by state for the jurisdictions with d ata. The table below shows the number and rate of fatal drug overdose deaths.

You can also see similar information for other types of drugs.

Note: A rate value of 9999 denotes that the value is suppressed. Rates based on less than 20 drug overdose deaths are suppressed to avoid presentation of unstable rates.

Related Topics: US CDC Topic List
Data Source: CDC (SUDORS).
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Number of Fatal Drug Overdose Deaths Involving All Drugs By State in 2021 (CDC)
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Number and Rate of Fatal Drug Overdose Deaths Involving All Drugs By State in 2021
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State Number of Deaths Age Adjusted Rate Per 100K
Alaska 277 38.3
Arizona 2687 38.3
Arkansas 662 22.9
Colorado 1713 28.7
Connecticut 1531 42.7
Delaware 511 53.4
Georgia 2397 22.3
Hawaii 252 17.2
Iowa 400 13.2
Kansas 673 24.1
Kentucky 2289 52.9
Maine 607 46.1
Maryland 2754 44.3
Massachusetts 2541 36.4
Michigan 2962 30.3
Minnesota 1240 22.5
Nebraska 188 10.2
Nevada 934 29.3
New Hampshire 421 30.8
New Jersey 3124 33.6
New Mexico 977 48.4
North Carolina 3854 37.5
Ohio 5411 47.8
Oklahoma 1014 26.8
Oregon 1083 25.6
Pennsylvania 5347 42.4
Rhode Island 447 41.1
South Dakota 82 9.8
Utah 588 19
Vermont 238 39.4
Virginia 2528 29.4
West Virginia 1457 87
District of Columbia 542 87.1