US Number and Rate of Fatal Drug Overdose Deaths By Type of Drug in 2020 (CDC)

Updated on February 2, 2026.

According to data from the CDC, the overall number of fatal drug overdose deaths in the US for all drugs was 48,260, and the age adjusted overdose death rate per 100,000 persons was 31.3 based on data from 34 jurisdictions. The following types of drugs were among the drugs that were involved with high number of overdose deaths: Any Opioids (39,959), Illegally-made Fentanyls (33,694), Any stimulants (23,163), and Cocaine (12,062).

The chart below shows the age-adjusted rate of overdose deaths per 100K by type of drug. The table below shows the number and the overdose death rate by type of drug.

You can see similar information for US states.

Related Topics: US CDC Topic List
Data Source: CDC (SUDORS).
See this for other years:
Age-Adjusted Rate of Fatal Drug Overdose Deaths Per 100K Persons By Type of Drug in 2020
Any Opioids
Illegally-made Fentanyls
Any stimulants
Cocaine
Methamphetamine
Any non-opioid sedatives
Prescription Opioids
Heroin
Benzodiazepines
Number and Rate of Fatal Drug Overdose Deaths By Type of Drug in 2020
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Type of Drug Number of Overdose Deaths Age Adjusted Overdose Death Rate Per 100K
All Drugs 48260 31.3
Any Opioids 39959 26
Illegally-made Fentanyls 33694 21.9
Heroin 8763 5.7
Prescription Opioids 9093 5.9
Any stimulants 23163 15.1
Cocaine 12062 7.8
Methamphetamine 11302 7.4
Any non-opioid sedatives 10473 6.8
Benzodiazepines 6735 4.4