SPHERA FUNDS MANAGEMENT LTD. - Stock Holdings in 13F Filings (SEC)
Updated on March 15, 2026.
Based on 13F Filings filed with the SEC on February 17, 2026, for the 2025 Q4 period, SPHERA FUNDS MANAGEMENT LTD. held in its portfolio 98 assets valued at $517,294,385 (i.e. $517.29M).
The most valuable assets in the portfolio included: TEVA PHARMACEUTICAL INDS LTD ($35.07M), BIOGEN INC ($16.67M), and MINERALYS THERAPEUTICS INC ($16.29M).
The chart below shows the top 10 valuable assets, and the table below shows the top 98 valuable assets.
You can see similar for other investment managers.
Related Topics: SEC Topic List.
Data Source: SEC.
SPHERA FUNDS MANAGEMENT LTD. - Stock Holdings in 13F Filings (SEC)
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| Name of Issuer | No. of Shares | Value ($) | Class |
|---|---|---|---|
| TEVA PHARMACEUTICAL INDS LTD | 1123525 | 35065215 | SPONSORED ADS |
| BIOGEN INC | 94738 | 16672941 | COM |
| MINERALYS THERAPEUTICS INC | 449003 | 16294319 | COM |
| SYNDAX PHARMACEUTICALS INC | 762563 | 16021449 | COM |
| NOVA LTD | 47846 | 15712148 | COM |
| ULTRAGENYX PHARMACEUTICAL IN | 650623 | 14964329 | COM |
| TOWER SEMICONDUCTOR LTD | 122513 | 14385476 | SHS NEW |
| COGENT BIOSCIENCES INC | 378500 | 13444320 | COM |
| ASTRAZENECA PLC | 135060 | 12416066 | SPONSORED ADR |
| PRAXIS PRECISION MEDICINES I | 40000 | 11789600 | COM NEW |
| SANOFI SA | 239515 | 11606897 | SPONSORED ADR |
| ELI LILLY & CO | 9040 | 9715107 | COM |
| AMICUS THERAPEUTICS INC | 658377 | 9375288 | COM |
| IMMATICS N.V | 861105 | 9041603 | SHS |
| BIOMARIN PHARMACEUTICAL INC | 147000 | 8736210 | COM |
| SPDR SERIES TRUST | 70000 | 8535100 | STATE STREET SPD |
| BRIDGEBIO PHARMA INC | 107746 | 8241492 | COM |
| ORIC PHARMACEUTICALS INC | 1004378 | 8215812 | COM |
| DYNE THERAPEUTICS INC | 392894 | 7685007 | COM |
| TREVI THERAPEUTICS INC | 598534 | 7493646 | COM |
| JOHNSON & JOHNSON | 35831 | 7415225 | COM |
| SAVARA INC | 1178164 | 7104329 | COM |
| SCHOLAR ROCK HLDG CORP | 158265 | 6971573 | COM |
| WAVE LIFE SCIENCES LTD | 408166 | 6938822 | SHS |
| CYBIN INC | 825576 | 6753212 | COM NEW |
| ANNEXON INC | 1316212 | 6607384 | COM |
| BIOCRYST PHARMACEUTICALS INC | 837889 | 6535534 | COM |
| CELLDEX THERAPEUTICS INC NEW | 239764 | 6511990 | COM NEW |
| SOLENO THERAPEUTICS INC | 136314 | 6311338 | COM |
| APELLIS PHARMACEUTICALS INC | 250961 | 6304140 | COM |
| NICE LTD | 55700 | 6296328 | SPONSORED ADR |
| GSK PLC | 122000 | 5982880 | SPONSORED ADR |
| ENPHASE ENERGY INC | 186500 | 5977325 | COM |
| NOVO-NORDISK A S | 115677 | 5885646 | ADR |
| CYTOKINETICS INC | 91717 | 5827698 | COM NEW |
| ABBVIE INC | 25256 | 5770743 | COM |
| SOLAREDGE TECHNOLOGIES INC | 196536 | 5670064 | COM |
| ACADIA PHARMACEUTICALS INC | 212202 | 5667915 | COM |
| VOR BIOPHARMA INC | 410417 | 5368254 | COM NEW |
| MERCK & CO INC | 48600 | 5115636 | COM |
| NOVARTIS AG | 37000 | 5101190 | SPONSORED ADR |
| FORTE BIOSCIENCES INC | 185869 | 5068648 | COM NEW |
| KODIAK SCIENCES INC | 175500 | 4906980 | COM |
| TANGO THERAPEUTICS INC | 544563 | 4824828 | COM |
| SOLAREDGE TECHNOLOGIES INC | 4000000 | 4699440 | NOTE 2.250% 7/0 |
| ASTRIA THERAPEUTICS INC | 355725 | 4656440 | COM |
| MEDIWOUND LTD | 230347 | 4252206 | SHS NEW |
| CAMTEK LTD | 39498 | 4200415 | ORD |
| REVOLUTION MEDICINES INC | 52500 | 4181625 | COM |
| ISHARES TR | 47000 | 4096520 | 20 YR TR BD ETF |
| ADVANCED MICRO DEVICES INC | 18040 | 3863446 | COM |
| CLIMB BIO INC | 932247 | 3728988 | COM |
| ALPHA COGNITION INC | 567616 | 3689504 | COM NEW |
| ENLIVEN THERAPEUTICS INC | 226765 | 3492181 | COM |
| PROTARA THERAPEUTICS INC | 650000 | 3464500 | COM STK |
| BROADCOM INC | 9755 | 3376206 | COM |
| ELEDON PHARMACEUTICALS INC | 2132131 | 3219518 | COM |
| BIOAGE LABS INC | 243035 | 3215353 | COM |
| CORVUS PHARMACEUTICALS INC | 407709 | 3139359 | COM |
| ELBIT SYS LTD | 5340 | 3084971 | ORD |
| KURA ONCOLOGY INC | 295522 | 3070474 | COM |
| MAZE THERAPEUTICS INC | 71843 | 2976455 | COM |
| ZIM INTEGRATED SHIPPING SERV | 136005 | 2887386 | SHS |
| STRUCTURE THERAPEUTICS INC | 41000 | 2851550 | SPONSORED ADS |
| EVOMMUNE INC | 166147 | 2844437 | COM SHS |
| VERASTEM INC | 343678 | 2653194 | COM NEW |
| AMGEN INC | 7500 | 2454825 | COM |
| NURIX THERAPEUTICS INC | 124000 | 2352280 | COM |
| ASCENDIS PHARMA A/S | 11000 | 2345640 | SPONSORED ADR |
| TENAX THERAPEUTICS INC | 190111 | 2317453 | COM NEW |
| JANUX THERAPEUTICS INC | 157840 | 2178192 | COM |
| PFIZER INC | 86000 | 2141400 | COM |
| TAYSHA GENE THERAPIES INC | 368146 | 2024803 | COM SHS |
| CONTINEUM THERAPEUTICS INC | 173475 | 1982819 | CL A |
| MADRIGAL PHARMACEUTICALS INC | 3300 | 1921722 | COM |
| PHARVARIS N V | 63953 | 1774696 | COM |
| VARONIS SYS INC | 52500 | 1722000 | COM |
| PRECISION BIOSCIENCES INC | 396116 | 1647843 | COM NEW |
| VENTYX BIOSCIENCES INC | 180114 | 1626429 | COM |
| ISHARES BITCOIN TRUST ETF | 30055 | 1492231 | SHS BEN INT |
| DAY ONE BIOPHARMACEUTICALS I | 145371 | 1354858 | COM |
| VOYAGER THERAPEUTICS INC | 339761 | 1335261 | COM |
| ENTRADA THERAPEUTICS INC | 110942 | 1140484 | COM |
| TENAYA THERAPEUTICS INC | 1500000 | 1067250 | COM |
| PERSPECTIVE THERAPEUTICS INC | 349973 | 962426 | COM NEW |
| BRISTOL-MYERS SQUIBB CO | 17500 | 943950 | COM |
| JASPER THERAPEUTICS INC | 485401 | 888284 | COM NEW |
| PEPGEN INC | 121467 | 790750 | COM |
| SHATTUCK LABS INC | 195212 | 712524 | COM |
| PALISADE BIO INC | 184100 | 432635 | COM |
| WEREWOLF THERAPEUTICS INC | 626810 | 397084 | COM |
| SKYE BIOSCIENCE INC | 478928 | 359052 | COM NEW |
| PRELUDE THERAPEUTICS INC | 122752 | 355981 | COM |
| APREA THERAPEUTICS INC | 270000 | 230310 | COM NEW |
| ONKURE THERAPEUTICS INC | 60454 | 175317 | COM CL A |
| MEREO BIOPHARMA GROUP PLC | 255400 | 106425 | SPON ADS |
| PROMIS NEUROSCIENCES INC | 11807 | 80586 | COM SHS |
| APPLIED THERAPEUTICS INC | 50000 | 5000 | COM |
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