Siren, L.L.C. - Stock Holdings in 13F Filings (SEC)
Updated on March 15, 2026.
Based on 13F Filings filed with the SEC on February 13, 2026, for the 2025 Q4 period, Siren, L.L.C. held in its portfolio 113 assets valued at $3,352,424,599 (i.e. $3.35B).
The most valuable assets in the portfolio included: Scholar Rock Holding Corp ($476.84M), Kymera Therapeutics Inc ($255.75M), and BeOne Medicines AG ($151.91M).
The chart below shows the top 10 valuable assets, and the table below shows the top 113 valuable assets.
You can see similar for other investment managers.
Related Topics: SEC Topic List.
Data Source: SEC.
Siren, L.L.C. - Stock Holdings in 13F Filings (SEC)
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| Name of Issuer | No. of Shares | Value ($) | Class |
|---|---|---|---|
| Scholar Rock Holding Corp | 10825013 | 476841823 | COM |
| Kymera Therapeutics Inc | 3286830 | 255748242 | COM |
| BeOne Medicines AG | 500000 | 151905000 | SPONSORED ADS |
| Edgewise Therapeutics Inc | 4529990 | 112411702 | COM |
| Revolution Medicines Inc | 1335075 | 106338724 | COM |
| Centessa Pharmaceuticals PLC | 4027517 | 100728200 | SPONSORED ADS |
| Arrowhead Pharmaceuticals Inc | 1500476 | 99616602 | COM |
| Bicara Therapeutics Inc | 5216969 | 87801588 | COM |
| Olema Pharmaceuticals Inc | 3300700 | 82517500 | COM |
| Disc Medicine Inc | 988401 | 78488923 | COM |
| Structure Therapeutics Inc | 1078698 | 75023446 | SPONSORED ADS |
| Tango Therapeutics Inc | 8165374 | 72345214 | COM |
| Arcus Biosciences Inc | 3007077 | 71658645 | COM |
| Stoke Therapeutics Inc | 2247347 | 71330794 | COM |
| Crinetics Pharmaceuticals Inc | 1507636 | 70180456 | COM |
| Dyne Therapeutics Inc | 3502941 | 68517526 | COM |
| Apellis Pharmaceuticals Inc | 2578396 | 64769308 | COM |
| Cogent Biosciences Inc | 1629279 | 57871990 | COM |
| Septerna Inc | 2000000 | 55760000 | COM |
| Taysha Gene Therapies Inc | 10129913 | 55714522 | COM SHS |
| Rhythm Pharmaceuticals Inc | 499975 | 53517324 | COM |
| Ascendis Pharma A/S | 235862 | 50295213 | SPONSORED ADR |
| RAPT Therapeutics Inc | 1375000 | 46571250 | COM NEW |
| Taboola.com Ltd | 9969495 | 45959372 | ORD SHS |
| Lexicon Pharmaceuticals Inc | 38918903 | 44756738 | COM NEW |
| Zymeworks Inc | 1680121 | 44237586 | COM |
| Solid Biosciences Inc | 7690405 | 43373884 | COM NEW |
| WAVE Life Sciences Ltd | 2450000 | 41650000 | SHS |
| Xenon Pharmaceuticals Inc | 812761 | 36427948 | COM |
| Dbv Technologies SA | 1857362 | 35605630 | SPONSORED ADS |
| Erasca Inc | 8757249 | 32576966 | COM |
| enGene Holdings Inc | 3336264 | 30126464 | COM |
| Trevi Therapeutics Inc | 2286867 | 28631575 | COM |
| Spyre Therapeutics Inc | 818598 | 26817270 | COM NEW |
| Mineralys Therapeutics Inc | 699999 | 25402964 | COM |
| Denali Therapeutics Inc | 1396513 | 23056430 | COM |
| Remitly Global Inc | 1618271 | 22332140 | COM |
| Fulcrum Therapeutics Inc | 1950000 | 22054500 | COM |
| Rapport Therapeutics Inc | 708469 | 21494949 | COM |
| Silence Therapeutics PLC | 2911438 | 17701543 | ADS |
| IHS Holding Limited | 2357520 | 17587099 | ORD SHS |
| Gossamer Bio Inc | 5208968 | 16147801 | COM |
| Upstream Bio Inc | 588450 | 15976418 | COM |
| Bicycle Therapeutics PLC | 2012752 | 14250284 | SPONSORED ADS |
| Monopar Therapeutics Inc | 212298 | 13863059 | COM NEW |
| Cullinan Therapeutics Inc | 1193410 | 12351794 | COM |
| Sionna Therapeutics Inc | 300000 | 12342000 | COM |
| Inhibikase Therapeutics Inc | 5850000 | 11992500 | COM NEW |
| NovaBridge Biosciences | 3000000 | 11940000 | SPONSORED ADS |
| Amazon.com Inc | 51500 | 11887230 | COM |
| Neumora Therapeutics Inc | 6288783 | 11256922 | COM |
| Mind Medicine (MindMed) Inc | 800000 | 10712000 | COM NEW |
| Benitec Biopharma Inc | 775000 | 10439250 | COM NEW |
| Invivyd Inc | 4000000 | 9880000 | COM |
| Taiwan Semiconductor Manufacturing Co Ltd | 27700 | 8417753 | SPONSORED ADS |
| Oric Pharmaceuticals Inc | 1007575 | 8241964 | COM |
| MapLight Therapeutics Inc | 450000 | 7904250 | COM |
| Palvella Therapeutics Inc | 75000 | 7850250 | COM |
| CrowdStrike Holdings Inc | 16500 | 7734540 | CL A |
| IONQ Inc | 170000 | 7627900 | COM |
| Seer Inc | 4000000 | 7320000 | COM CL A |
| Microsoft Corp | 15000 | 7254300 | COM |
| PDD Holdings Inc | 63401 | 7189039 | SPONSORED ADS |
| Lexeo Therapeutics Inc | 720622 | 7155776 | COM |
| NVIDIA Corp | 37485 | 6990953 | COM |
| Salesforce Inc | 26100 | 6914151 | COM |
| Compass Pathways PLC | 1000000 | 6900000 | SPONSORED ADS |
| BillionToOne Inc | 83833 | 6860893 | CL A |
| Workiva Inc | 79123 | 6824359 | COM CL A |
| Zura Bio Ltd | 1300000 | 6812000 | CLASS A ORD SHS |
| vTv Therapeutics Inc | 163000 | 6518370 | CL A NEW |
| Alphabet Inc | 20703 | 6480039 | CAP STK CL A |
| Nebius Group NV | 76218 | 6379828 | SHS CLASS A |
| Savara Inc | 1000000 | 6030000 | COM |
| X4 Pharmaceuticals Inc | 1500000 | 6000000 | COM NEW |
| Jfrog Ltd | 93616 | 5847255 | ORD SHS |
| ServiceNow Inc | 35630 | 5458160 | COM |
| Tenax Therapeutics Inc | 427141 | 5206849 | COM NEW |
| Whitehawk Therapeutics Inc | 2082000 | 5038440 | COM |
| Dynatrace Inc | 115229 | 4994025 | COM NEW |
| Datadog Inc | 36425 | 4953436 | CL A COM |
| Alumis Inc | 500000 | 4880000 | COM |
| Meta Platforms Inc | 7169 | 4732185 | CL A |
| PepGen Inc | 700000 | 4557000 | COM |
| Sagimet Biosciences Inc | 724771 | 4290644 | COM SER A |
| Adobe Inc | 12051 | 4217729 | COM |
| Foghorn Therapeutics Inc | 720720 | 3891888 | COM |
| GitLab Inc | 99000 | 3715470 | CLASS A COM |
| Kalaris Therapeutics Inc | 435798 | 3678135 | COM |
| New Oriental Education & Technology Group Inc | 62000 | 3411860 | SPON ADR |
| Agenus Inc | 1064250 | 3341745 | COM NEW |
| Medline Inc | 75000 | 3150000 | COM CL A |
| Korro Bio Inc | 347718 | 2785221 | COM |
| Cellebrite DI Ltd | 150000 | 2705550 | ORDINARY SHARES |
| Rani Therapeutics Holdings Inc | 2000000 | 2700000 | COM CL A |
| Zscaler Inc | 12000 | 2699040 | COM |
| Black Diamond Therapeutics Inc | 1046517 | 2543036 | COM |
| monday.com Ltd | 17000 | 2508520 | SHS |
| Broadcom Inc | 7000 | 2422700 | COM |
| Qualcomm Inc | 14000 | 2394700 | COM |
| Arm Holdings PLC | 21500 | 2350165 | SPONSORED ADS |
| Ke Holdings Inc | 145000 | 2285200 | SPONSORED ADS |
| Instil Bio Inc | 203933 | 2243263 | COM NEW |
| Palo Alto Networks Inc | 11450 | 2109090 | COM |
| CoreWeave Inc | 27500 | 1969275 | COM CL A |
| IREN Ltd | 43100 | 1627887 | ORDINARY SHARES |
| Varonis Systems Inc | 37500 | 1230000 | COM |
| Primo Brands Corp | 75000 | 1226250 | CLASS A COM SHS |
| Generation Bio Inc | 201419 | 1144060 | COM NEW |
| Figma Inc | 25000 | 934250 | CLASS A COM STK |
| Tesla Inc | 1500 | 674580 | COM |
| Caribou Biosciences Inc | 105347 | 167502 | COM |
| Cyclerion Therapeutics Inc | 115603 | 146816 | COM |
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