RTW INVESTMENTS, LP - Stock Holdings in 13F Filings (SEC)
Updated on March 15, 2026.
Based on 13F Filings filed with the SEC on February 17, 2026, for the 2025 Q4 period, RTW INVESTMENTS, LP held in its portfolio 91 assets valued at $9,983,316,876 (i.e. $9.98B).
The most valuable assets in the portfolio included: MADRIGAL PHARMACEUTICALS INC ($1.16B), INSMED INC ($842.86M), and PTC THERAPEUTICS INC ($588.42M).
The chart below shows the top 10 valuable assets, and the table below shows the top 91 valuable assets.
You can see similar for other investment managers.
Related Topics: SEC Topic List.
Data Source: SEC.
RTW INVESTMENTS, LP - Stock Holdings in 13F Filings (SEC)
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| Name of Issuer | No. of Shares | Value ($) | Class |
|---|---|---|---|
| MADRIGAL PHARMACEUTICALS INC | 1993687 | 1161003688 | COM |
| INSMED INC | 4842879 | 842854661 | COM PAR $.01 |
| PTC THERAPEUTICS INC | 7746415 | 588417683 | COM |
| ARGENX SE | 673497 | 566377302 | SPONSORED ADR |
| PROTAGONIST THERAPEUTICS INC | 5059053 | 441857689 | COM |
| NATERA INC | 1500000 | 343635000 | COM |
| RADNET INC | 3938500 | 281011975 | COM |
| TARSUS PHARMACEUTICALS INC | 3335320 | 273096002 | COM |
| COGENT BIOSCIENCES INC | 7592241 | 269676400 | COM |
| PENUMBRA INC | 866499 | 269403204 | COM |
| IRHYTHM TECHNOLOGIES INC | 1181990 | 209732306 | COM |
| APOGEE THERAPEUTICS INC | 2712097 | 204709082 | COM |
| APELLIS PHARMACEUTICALS INC | 7666764 | 192589112 | COM |
| ACADIA PHARMACEUTICALS INC | 7144524 | 190830236 | COM |
| ESTABLISHMENT LABS HLDGS INC | 2588831 | 188674003 | COM |
| STOKE THERAPEUTICS INC | 5546856 | 176057209 | COM |
| REPLIGEN CORP | 1064000 | 174347040 | COM |
| CYTOKINETICS INC | 2721158 | 172902379 | COM NEW |
| IMMUNOCORE HLDGS PLC | 4869798 | 169030689 | ADS |
| AXSOME THERAPEUTICS INC | 888001 | 162184503 | COM |
| GUARDANT HEALTH INC | 1481033 | 151272711 | COM |
| NEUROCRINE BIOSCIENCES INC | 1062072 | 150633672 | COM |
| SPYRE THERAPEUTICS INC | 4171996 | 136674589 | COM NEW |
| ZAI LAB LTD | 6959032 | 122757324 | ADR |
| IMMATICS N.V | 11433354 | 120050217 | SHS |
| BELITE BIO INC | 715332 | 114424507 | SPONSORED ADS |
| UROGEN PHARMA LTD | 4543895 | 106418021 | COM |
| XENCOR INC | 6777461 | 103762928 | COM |
| INSULET CORP | 324600 | 92264304 | COM |
| TAYSHA GENE THERAPIES INC | 16398297 | 90190634 | COM SHS |
| MASIMO CORP | 683294 | 88869218 | COM |
| UNIQURE NV | 3711462 | 88815286 | SHS |
| STRYKER CORPORATION | 245000 | 86110150 | COM |
| CG ONCOLOGY INC | 2012127 | 83543513 | COM |
| CASTLE BIOSCIENCES INC | 2115237 | 82282719 | COM |
| IMMUNOVANT INC | 3177850 | 80780947 | COM |
| BETA BIONICS INC | 2500000 | 76175000 | COM |
| GH RESEARCH PLC | 5933815 | 75359451 | ORDINARY SHARES |
| REPLIMUNE GROUP INC | 7140352 | 69404221 | COM |
| ULTRAGENYX PHARMACEUTICAL IN | 3000139 | 69003197 | COM |
| CRINETICS PHARMACEUTICALS IN | 1351326 | 62904225 | COM |
| ORUKA THERAPEUTICS INC | 2058148 | 62382466 | COM |
| ROCKET PHARMACEUTICALS INC | 17687772 | 62084080 | COM |
| COMPASS PATHWAYS PLC | 8757390 | 60425991 | SPONSORED ADS |
| INTUITIVE SURGICAL INC | 101228 | 57331490 | COM NEW |
| RAPT THERAPEUTICS INC | 1637165 | 55450779 | COM NEW |
| CELCUITY INC | 550160 | 54872958 | COM |
| VERASTEM INC | 6576306 | 50769082 | COM NEW |
| ALKERMES PLC | 1672356 | 46792521 | SHS |
| CENTESSA PHARMACEUTICALS PLC | 1790837 | 44788833 | SPONSORED ADS |
| KODIAK SCIENCES INC | 1487933 | 41602607 | COM |
| AQUESTIVE THERAPEUTICS INC | 6250000 | 40375000 | COM |
| ARROWHEAD PHARMACEUTICALS IN | 584716 | 38819295 | COM |
| SAVARA INC | 5952380 | 35892851 | COM |
| ORCHESTRA BIOMED HLDGS INC | 8306063 | 34470161 | COM |
| NEUROGENE INC | 1362456 | 28066594 | COM |
| WAVE LIFE SCIENCES LTD | 1350000 | 22950000 | SHS |
| JADE BIOSCIENCES INC | 1449273 | 22362282 | COM NEW |
| EVOMMUNE INC | 1283671 | 21976448 | COM SHS |
| KYMERA THERAPEUTICS INC | 240000 | 18674400 | COM |
| FULGENT GENETICS INC | 705027 | 18521059 | COM |
| CULLINAN THERAPEUTICS INC | 1705960 | 17656686 | COM |
| HINGE HEALTH INC | 353500 | 16420075 | CL A |
| BEAM THERAPEUTICS INC | 570394 | 15811322 | COM |
| HEARTFLOW INC | 495000 | 14429250 | COM |
| COMPASS THERAPEUTICS INC | 2500000 | 13425000 | COM |
| TANGO THERAPEUTICS INC | 1491228 | 13212280 | COM |
| LUMEXA IMAGING HOLDINGS INC | 650000 | 12025000 | COM |
| LARIMAR THERAPEUTICS INC | 3125000 | 11906250 | COM |
| TEMPUS AI INC | 200000 | 11810000 | CL A |
| KALARIS THERAPEUTICS INC | 1300000 | 10972000 | COM |
| IQVIA HLDGS INC | 46000 | 10368860 | COM |
| PERCEPTIVE CAP SOLUTIONS COR | 742500 | 9674775 | CL A ORD SHS |
| ATAI BECKLEY NV | 2000000 | 8180000 | SHS |
| ALLURION TECHNOLOGIES INC | 5891430 | 7246459 | COMMON STOCK |
| CAPRICOR THERAPEUTICS INC | 250000 | 7215000 | COM NEW |
| STRUCTURE THERAPEUTICS INC | 100000 | 6955000 | SPONSORED ADS |
| INVENTIVA SA | 1298701 | 6038960 | ADS |
| MILESTONE PHARMACEUTICALS IN | 2506102 | 5062326 | COM |
| EXAGEN INC | 790462 | 4806009 | COM |
| TENAX THERAPEUTICS INC | 378346 | 4612038 | COM NEW |
| CRESCENT BIOPHARMA INC. | 372856 | 4422072 | COM |
| MIND MEDICINE MINDMED INC | 300000 | 4017000 | COM NEW |
| 4D MOLECULAR THERAPEUTICS IN | 475737 | 3568028 | COM |
| CORVUS PHARMACEUTICALS INC | 447607 | 3446574 | COM |
| OMADA HEALTH INC | 200000 | 3156000 | COM |
| MEDLINE INC | 70000 | 2940000 | COM CL A |
| DISC MEDICINE INC | 30000 | 2382300 | COM |
| IMAGENEBIO INC | 334445 | 2307671 | COM |
| ERASCA INC | 146651 | 545542 | COM |
| ROCKET PHARMACEUTICALS INC | 350000 | 8505 | *W EXP 09/02/202 |
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