Rock Springs Capital Management LP - Stock Holdings in 13F Filings (SEC)
Updated on March 15, 2026.
Based on 13F Filings filed with the SEC on February 17, 2026, for the 2025 Q4 period, Rock Springs Capital Management LP held in its portfolio 97 assets valued at $1,950,203,715 (i.e. $1.95B).
The most valuable assets in the portfolio included: ELI LILLY & CO ($113.27M), REVOLUTION MEDICINES INC ($106.35M), and ARGENX SE ($86.83M).
The chart below shows the top 10 valuable assets, and the table below shows the top 97 valuable assets.
You can see similar for other investment managers.
Related Topics: SEC Topic List.
Data Source: SEC.
Rock Springs Capital Management LP - Stock Holdings in 13F Filings (SEC)
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| Name of Issuer | No. of Shares | Value ($) | Class |
|---|---|---|---|
| ELI LILLY & CO | 105400 | 113271272 | COM |
| REVOLUTION MEDICINES INC | 1335270 | 106354256 | COM |
| ARGENX SE | 103250 | 86828088 | SPONSORED ADR |
| TRAVERE THERAPEUTICS INC | 2210322 | 84456404 | COM |
| MADRIGAL PHARMACEUTICALS INC | 139618 | 81305146 | COM |
| RHYTHM PHARMACEUTICALS INC | 695010 | 74393870 | COM |
| EXACT SCIENCES CORP | 601800 | 61118808 | COM |
| MIRUM PHARMACEUTICALS INC | 762294 | 60213603 | COM |
| INSMED INC | 319250 | 55562270 | COM PAR $.01 |
| STRUCTURE THERAPEUTICS INC | 748236 | 52039814 | SPONSORED ADS |
| INTUITIVE SURGICAL INC | 82000 | 46441520 | COM NEW |
| CIDARA THERAPEUTICS INC | 204878 | 45255501 | COM NEW |
| ASCENDIS PHARMA A/S | 203500 | 43394340 | SPONSORED ADR |
| IRHYTHM TECHNOLOGIES INC | 235000 | 41698400 | COM |
| KYMERA THERAPEUTICS INC | 496871 | 38661533 | COM |
| BOSTON SCIENTIFIC CORP | 399050 | 38049418 | COM |
| PENUMBRA INC | 120500 | 37464655 | COM |
| XENON PHARMACEUTICALS INC | 787788 | 35308658 | COM |
| SCHOLAR ROCK HLDG CORP | 733477 | 32309662 | COM |
| COGENT BIOSCIENCES INC | 849030 | 30157546 | COM |
| ULTRAGENYX PHARMACEUTICAL IN | 1267241 | 29146543 | COM |
| VERA THERAPEUTICS INC | 568579 | 28792841 | CL A |
| ALNYLAM PHARMACEUTICALS INC | 71250 | 28332563 | COM |
| AMICUS THERAPEUTICS INC | 1929931 | 27482217 | COM |
| SPDR SERIES TRUST | 222000 | 27068460 | STATE STREET SPD |
| TENET HEALTHCARE CORP | 125000 | 24840000 | COM NEW |
| DEXCOM INC | 347300 | 23050301 | COM |
| AGIOS PHARMACEUTICALS INC | 799163 | 21753217 | COM |
| TARSUS PHARMACEUTICALS INC | 260344 | 21316967 | COM |
| COMPASS THERAPEUTICS INC | 3927202 | 21089075 | COM |
| NEWAMSTERDAM PHARMA COMPANY | 588794 | 20654894 | ORDINARY SHARES |
| AZENTA INC | 569100 | 18928266 | COM |
| CELLDEX THERAPEUTICS INC NEW | 692538 | 18809332 | COM NEW |
| CARIS LIFE SCIENCES INC | 687500 | 18548750 | COM |
| ZENAS BIOPHARMA INC | 502077 | 18230416 | COM |
| DYNE THERAPEUTICS INC | 912955 | 17857400 | COM |
| NEUROCRINE BIOSCIENCES INC | 125500 | 17799665 | COM |
| PHARVARIS N V | 623402 | 17299406 | COM |
| MINERALYS THERAPEUTICS INC | 427596 | 15517459 | COM |
| PHREESIA INC | 876600 | 14832072 | COM |
| ZAI LAB LTD | 811546 | 14315671 | ADR |
| DANAHER CORPORATION | 61500 | 14078580 | COM |
| UNITEDHEALTH GROUP INC | 40800 | 13468488 | COM |
| ARDELYX INC | 2299473 | 13405928 | COM |
| ACLARIS THERAPEUTICS INC | 4453741 | 13405760 | COM |
| SUMMIT THERAPEUTICS INC | 710000 | 12417900 | COM |
| ENLIVEN THERAPEUTICS INC | 798405 | 12295437 | COM |
| INSPIRE MED SYS INC | 131000 | 12082130 | COM |
| OMADA HEALTH INC | 740000 | 11677200 | COM |
| SOLENO THERAPEUTICS INC | 247053 | 11438554 | COM |
| ARCELLX INC | 169859 | 11074807 | COMMON STOCK |
| EVOLENT HEALTH INC | 2675000 | 10700000 | CL A |
| GOSSAMER BIO INC | 3266960 | 10127576 | COM |
| MBX BIOSCIENCES INC | 282624 | 8913961 | COM |
| CENTESSA PHARMACEUTICALS PLC | 324015 | 8103615 | SPONSORED ADS |
| HEARTFLOW INC | 277700 | 8094955 | COM |
| BRIDGEBIO PHARMA INC | 103500 | 7916715 | COM |
| REGENERON PHARMACEUTICALS | 10100 | 7795887 | COM |
| IMMUNOME INC | 347666 | 7467866 | COM |
| RAPT THERAPEUTICS INC | 213731 | 7239069 | COM NEW |
| BICARA THERAPEUTICS INC | 429095 | 7221669 | COM |
| EDWARDS LIFESCIENCES CORP | 82500 | 7033125 | COM |
| ALPHATEC HLDGS INC | 302500 | 6364600 | COM NEW |
| AMYLYX PHARMACEUTICALS INC | 499764 | 6037149 | COM |
| THERMO FISHER SCIENTIFIC INC | 10000 | 5794500 | COM |
| JANUX THERAPEUTICS INC | 358798 | 4951412 | COM |
| SURGERY PARTNERS INC | 310000 | 4789500 | COM |
| EYEPOINT INC | 258739 | 4727162 | COM NEW |
| PTC THERAPEUTICS INC | 61879 | 4700329 | COM |
| AGILON HEALTH INC | 6500000 | 4476550 | COM |
| MERSANA THERAPEUTICS INC | 152586 | 4414313 | COM |
| TERNS PHARMACEUTICALS INC | 108481 | 4382632 | COM |
| ARCUS BIOSCIENCES INC | 180000 | 4289400 | COM |
| EDAP TMS S A | 1286500 | 4232585 | SPONSORED ADR |
| OCULAR THERAPEUTIX INC | 345820 | 4198255 | COM |
| LENZ THERAPEUTICS INC | 257460 | 4119360 | COM |
| TALPHERA INC | 3589186 | 4091672 | COM NEW |
| SIONNA THERAPEUTICS INC | 99429 | 4090509 | COM |
| THERAVANCE BIOPHARMA INC | 208771 | 3906105 | COM |
| ALKERMES PLC | 139228 | 3895599 | SHS |
| APELLIS PHARMACEUTICALS INC | 150500 | 3780560 | COM |
| INDIVIOR PLC | 105100 | 3770988 | ORD |
| ERASCA INC | 951710 | 3540361 | COM |
| TANGO THERAPEUTICS INC | 386915 | 3428067 | COM |
| OLEMA PHARMACEUTICALS INC | 98240 | 2456000 | COM |
| CYTOKINETICS INC | 35853 | 2278100 | COM NEW |
| VAXCYTE INC | 47000 | 2168580 | COM |
| NEUROGENE INC | 104339 | 2149383 | COM |
| JASPER THERAPEUTICS INC | 1100726 | 2014329 | COM NEW |
| ROIVANT SCIENCES LTD | 88750 | 1925875 | SHS |
| CORCEPT THERAPEUTICS INC | 50250 | 1748700 | COM |
| ACADIA HEALTHCARE COMPANY IN | 120000 | 1702800 | COM |
| TEVA PHARMACEUTICAL INDS LTD | 45500 | 1420055 | SPONSORED ADS |
| MOONLAKE IMMUNOTHERAPEUTICS | 61700 | 813206 | CLASS A ORD |
| LEGEND BIOTECH CORP | 33800 | 734812 | SPONSORED ADS |
| JAZZ PHARMACEUTICALS PLC | 1750 | 297500 | SHS USD |
| NUVATION BIO INC | 134028 | 44229 | *W EXP 02/10/202 |
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