ORBIMED ADVISORS LLC - Stock Holdings in 13F Filings (SEC)
Updated on March 15, 2026.
Based on 13F Filings filed with the SEC on February 17, 2026, for the 2025 Q4 period, ORBIMED ADVISORS LLC held in its portfolio 105 assets valued at $4,899,391,958 (i.e. $4.90B).
The most valuable assets in the portfolio included: EDGEWISE THERAPEUTICS INC ($385.09M), ELI LILLY & CO ($323.69M), and BOSTON SCIENTIFIC CORP ($230.68M).
The chart below shows the top 10 valuable assets, and the table below shows the top 105 valuable assets.
You can see similar for other investment managers.
Related Topics: SEC Topic List.
Data Source: SEC.
ORBIMED ADVISORS LLC - Stock Holdings in 13F Filings (SEC)
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| Name of Issuer | No. of Shares | Value ($) | Class |
|---|---|---|---|
| EDGEWISE THERAPEUTICS INC | 15518492 | 385091379 | COM |
| ELI LILLY & CO | 301200 | 323693616 | COM |
| BOSTON SCIENTIFIC CORP | 2419300 | 230680255 | COM |
| SINOVAC BIOTECH LTD | 2718735 | 184466170 | SHS |
| EDWARDS LIFESCIENCES CORP | 1992900 | 169894725 | COM |
| UPSTREAM BIO INC | 5693589 | 154580941 | COM |
| INTUITIVE SURGICAL INC | 263400 | 149179224 | COM NEW |
| SIONNA THERAPEUTICS INC | 3561655 | 146526487 | COM |
| MBX BIOSCIENCES INC | 3935203 | 124116303 | COM |
| ARGENX SE | 146000 | 122778700 | SPONSORED ADR |
| ENLIVEN THERAPEUTICS INC | 7959538 | 122576885 | COM |
| ALNYLAM PHARMACEUTICALS INC | 288800 | 114841320 | COM |
| STRYKER CORPORATION | 325000 | 114227750 | COM |
| ARS PHARMACEUTICALS INC | 8288510 | 96561142 | COM |
| TERNS PHARMACEUTICALS INC | 2153300 | 86993320 | COM |
| DISC MEDICINE INC | 1067550 | 84774146 | COM |
| CARIS LIFE SCIENCES INC | 3116011 | 84069977 | COM |
| NATERA INC | 365800 | 83801122 | COM |
| COMPASS THERAPEUTICS INC | 15219994 | 81731368 | COM |
| STRUCTURE THERAPEUTICS INC | 1161803 | 80803399 | SPONSORED ADS |
| DANAHER CORPORATION | 299800 | 68630216 | COM |
| CG ONCOLOGY INC | 1516550 | 62967156 | COM |
| APELLIS PHARMACEUTICALS INC | 2429868 | 61038284 | COM |
| ARRIVENT BIOPHARMA INC | 3027328 | 60909839 | COM |
| THE CIGNA GROUP | 205000 | 56422150 | COM |
| RAPT THERAPEUTICS INC | 1642891 | 55644718 | COM NEW |
| CORVUS PHARMACEUTICALS INC | 7165006 | 55170546 | COM |
| UNITED THERAPEUTICS CORP DEL | 105200 | 51258700 | COM |
| ABIVAX SA | 367900 | 49613155 | SPONSORED ADS |
| ROIVANT SCIENCES LTD | 2190907 | 47542682 | SHS |
| CRINETICS PHARMACEUTICALS IN | 999000 | 46503450 | COM |
| AXSOME THERAPEUTICS INC | 253121 | 46230019 | COM |
| EYEPOINT INC | 2468314 | 45096097 | COM NEW |
| AVIDITY BIOSCIENCES INC | 619530 | 44686699 | COM |
| NEUROCRINE BIOSCIENCES INC | 314240 | 44568659 | COM |
| DYNE THERAPEUTICS INC | 2202184 | 43074719 | COM |
| BRISTOL-MYERS SQUIBB CO | 775000 | 41803500 | COM |
| PFIZER INC | 1652900 | 41157210 | COM |
| TREVI THERAPEUTICS INC | 3190700 | 39947564 | COM |
| NEUROPACE INC | 2406335 | 37153812 | COM |
| ASCENDIS PHARMA A/S | 171977 | 36672375 | SPONSORED ADR |
| EXACT SCIENCES CORP | 351716 | 35720277 | COM |
| MINERALYS THERAPEUTICS INC | 980400 | 35578716 | COM |
| ELEVANCE HEALTH INC FORMERLY | 99100 | 34739505 | COM |
| FORTE BIOSCIENCES INC | 1196955 | 32640963 | COM NEW |
| PRELUDE THERAPEUTICS INC | 10909256 | 31636842 | COM |
| CYBIN INC | 3840500 | 31415290 | COM NEW |
| ORIC PHARMACEUTICALS INC | 3641756 | 29789564 | COM |
| KRYSTAL BIOTECH INC | 119800 | 29535492 | COM |
| PRAXIS PRECISION MEDICINES I | 94500 | 27852930 | COM NEW |
| JANUX THERAPEUTICS INC | 1954426 | 26971079 | COM |
| THERMO FISHER SCIENTIFIC INC | 46500 | 26944425 | COM |
| BRUKER CORP | 555789 | 26183220 | COM |
| RHYTHM PHARMACEUTICALS INC | 239800 | 25668192 | COM |
| SHATTUCK LABS INC | 6306127 | 23017364 | COM |
| ESPERION THERAPEUTICS INC NE | 5965498 | 22072343 | COM |
| AVALO THERAPEUTICS INC | 1187300 | 21561368 | COM NEW |
| LEXEO THERAPEUTICS INC | 2125000 | 21101250 | COM |
| ADC THERAPEUTICS SA | 5822854 | 20554675 | SHS |
| UROGEN PHARMA LTD | 875487 | 20503906 | COM |
| XENON PHARMACEUTICALS INC | 447200 | 20043504 | COM |
| BRIGHTSPRING HEALTH SVCS INC | 488500 | 18294325 | COM |
| VERA THERAPEUTICS INC | 353500 | 17901240 | CL A |
| UNIQURE NV | 737400 | 17645982 | SHS |
| PRELUDE THERAPEUTICS INC | 5680186 | 16472539 | NONVOTING |
| MIND MEDICINE MINDMED INC | 1226700 | 16425513 | COM NEW |
| KEROS THERAPEUTICS INC | 804212 | 16373756 | COM |
| CARLSMED INC | 1252600 | 15469610 | COM |
| CYTOMX THERAPEUTICS INC | 3525650 | 15019269 | COM |
| VIR BIOTECHNOLOGY INC | 2380715 | 14355711 | COM |
| BIOCRYST PHARMACEUTICALS INC | 1741800 | 13586040 | COM |
| COGENT BIOSCIENCES INC | 371000 | 13177920 | COM |
| CORBUS PHARMACEUTICALS HLDGS | 1597287 | 13001916 | COM NEW |
| TARSUS PHARMACEUTICALS INC | 154400 | 12642272 | COM |
| RELMADA THERAPEUTICS INC | 2610600 | 12609198 | COM |
| TECTONIC THERAPEUTIC INC | 574600 | 11986156 | COM |
| ALUMIS INC | 1102730 | 10762645 | COM |
| BIOAGE LABS INC | 790901 | 10463620 | COM |
| AMICUS THERAPEUTICS INC | 729900 | 10393776 | COM |
| WHITEHAWK THERAPEUTICS INC | 4166000 | 10081720 | COM |
| ADICET BIO INC | 1027944 | 8655288 | COM NEW |
| REPARE THERAPEUTICS INC | 3322488 | 8638469 | COM |
| CELCUITY INC | 85664 | 8544127 | COM |
| JADE BIOSCIENCES INC | 531163 | 8195845 | COM NEW |
| KINIKSA PHARMACEUTICALS INTL | 187199 | 7721959 | ORD SHS CL A |
| Q32 BIO INC | 2252987 | 7479917 | COM |
| PMV PHARMACEUTICALS INC | 4975291 | 6219114 | COM |
| KALVISTA PHARMACEUTICALS INC | 382400 | 6175760 | COM |
| PHARVARIS N V | 205400 | 5699850 | COM |
| INSPIREMD INC | 3133405 | 5577461 | COM |
| INSMED INC | 25400 | 4420616 | COM PAR $.01 |
| PALISADE BIO INC | 1871420 | 4397837 | COM |
| IMAGENEBIO INC | 530713 | 3661920 | NONVOTING |
| BICARA THERAPEUTICS INC | 209100 | 3519153 | COM |
| CULLINAN THERAPEUTICS INC | 270006 | 2794562 | COM |
| C4 THERAPEUTICS INC | 1404902 | 2683363 | COM STK |
| IMAGENEBIO INC | 378556 | 2612036 | COM |
| ALTO NEUROSCIENCE INC | 125000 | 2225000 | COM SHS |
| REVOLUTION MEDICINES INC | 25900 | 2062935 | COM |
| VISTAGEN THERAPEUTICS INC | 3105200 | 2055332 | COM |
| OCULAR THERAPEUTIX INC | 157300 | 1909622 | COM |
| PROTAGONIST THERAPEUTICS INC | 21700 | 1895278 | COM |
| PTC THERAPEUTICS INC | 23200 | 1762272 | COM |
| MAPLIGHT THERAPEUTICS INC | 56000 | 952000 | COM |
| TRAWS PHARMA INC | 605531 | 684250 | COM NEW |
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