HighVista Strategies LLC - Stock Holdings in 13F Filings (SEC)
Updated on March 15, 2026.
Based on 13F Filings filed with the SEC on February 17, 2026, for the 2025 Q4 period, HighVista Strategies LLC held in its portfolio 145 assets valued at $388,309,219 (i.e. $388.31M).
The most valuable assets in the portfolio included: INVESCO DB COMMDY INDX TRCK ($23.64M), STRUCTURE THERAPEUTICS INC ($13.42M), and COGENT BIOSCIENCES INC ($11.96M).
The chart below shows the top 10 valuable assets, and the table below shows the top 145 valuable assets.
You can see similar for other investment managers.
Related Topics: SEC Topic List.
Data Source: SEC.
HighVista Strategies LLC - Stock Holdings in 13F Filings (SEC)
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| Name of Issuer | No. of Shares | Value ($) | Class |
|---|---|---|---|
| INVESCO DB COMMDY INDX TRCK | 1057238 | 23639842 | UNIT |
| STRUCTURE THERAPEUTICS INC | 193001 | 13423219 | SPONSORED ADS |
| COGENT BIOSCIENCES INC | 336667 | 11958412 | COM |
| VIRIDIAN THERAPEUTICS INC | 372472 | 11591329 | COM |
| ABIVAX SA | 72185 | 9734508 | SPONSORED ADS |
| REVOLUTION MEDICINES INC | 120240 | 9577116 | COM |
| PRAXIS PRECISION MEDICINES I | 25841 | 7616376 | COM NEW |
| NUVALENT INC | 73287 | 7371939 | COM |
| CYTOKINETICS INC | 114564 | 7279396 | COM NEW |
| TERNS PHARMACEUTICALS INC | 175462 | 7088665 | COM |
| MAZE THERAPEUTICS INC | 170353 | 7057724 | COM |
| INSMED INC | 39400 | 6857176 | COM PAR $.01 |
| APOGEE THERAPEUTICS INC | 89229 | 6735005 | COM |
| PROTAGONIST THERAPEUTICS INC | 73545 | 6423420 | COM |
| SOLENO THERAPEUTICS INC | 135069 | 6253695 | COM |
| SPYRE THERAPEUTICS INC | 188206 | 6165629 | COM NEW |
| BRIDGEBIO PHARMA INC | 80205 | 6134880 | COM |
| OLEMA PHARMACEUTICALS INC | 241489 | 6037225 | COM |
| IMMUNOVANT INC | 221883 | 5640266 | COM |
| LIQUIDIA CORPORATION | 156003 | 5380543 | COM NEW |
| VAXCYTE INC | 114049 | 5262221 | COM |
| CIDARA THERAPEUTICS INC | 22928 | 5064566 | COM NEW |
| ARCELLX INC | 75002 | 4890130 | COMMON STOCK |
| RELAY THERAPEUTICS INC | 545079 | 4611368 | COM |
| RHYTHM PHARMACEUTICALS INC | 42867 | 4588483 | COM |
| MINERALYS THERAPEUTICS INC | 124544 | 4519702 | COM |
| PHARVARIS N V | 162370 | 4505768 | COM |
| TARSUS PHARMACEUTICALS INC | 53564 | 4385821 | COM |
| EDGEWISE THERAPEUTICS INC | 171137 | 4246765 | COM |
| OCULAR THERAPEUTIX INC | 344067 | 4176974 | COM |
| AGIOS PHARMACEUTICALS INC | 147662 | 4019360 | COM |
| AMAZON COM INC | 17397 | 4015575 | COM |
| APELLIS PHARMACEUTICALS INC | 150776 | 3787493 | COM |
| GUARDANT HEALTH INC | 36758 | 3754462 | COM |
| STOKE THERAPEUTICS INC | 115539 | 3667208 | COM |
| COMPASS PATHWAYS PLC | 498933 | 3442637 | SPONSORED ADS |
| MICROSOFT CORP | 6537 | 3161424 | COM |
| LB PHARMACEUTICALS INC | 140107 | 3118782 | COM SHS |
| PALISADE BIO INC | 1300031 | 3055073 | COM |
| GH RESEARCH PLC | 240524 | 3054655 | ORDINARY SHARES |
| ARGENX SE | 3588 | 3017329 | SPONSORED ADR |
| XOMA ROYALTY CORPORATION | 112917 | 3002463 | COM NEW |
| TRANSDIGM GROUP INC | 2175 | 2892424 | COM |
| AVIDITY BIOSCIENCES INC | 40020 | 2886643 | COM |
| AMYLYX PHARMACEUTICALS INC | 238812 | 2884849 | COM |
| BRIDGEBIO ONCOLOGY THERAPEUT | 229263 | 2870372 | COM NEW |
| NVIDIA CORPORATION | 14220 | 2652030 | COM |
| SALESFORCE INC | 8613 | 2281670 | COM |
| VISA INC | 6291 | 2206316 | COM CL A |
| SEPTERNA INC | 78682 | 2193654 | COM |
| AXSOME THERAPEUTICS INC | 11131 | 2032965 | COM |
| DIANTHUS THERAPEUTICS INC | 48484 | 1998026 | COM |
| ALPHABET INC | 6277 | 1969723 | CAP STK CL C |
| BROADCOM INC | 5639 | 1951658 | COM |
| ROCKET COS INC | 97430 | 1886245 | COM CL A |
| UNION PAC CORP | 8058 | 1863977 | COM |
| HEWLETT PACKARD ENTERPRISE C | 76181 | 1829867 | COM |
| AMRIZE LTD | 33468 | 1809949 | SHS |
| AVALO THERAPEUTICS INC | 95631 | 1736659 | COM NEW |
| FLOWSERVE CORP | 24958 | 1731586 | COM |
| XPO INC | 12723 | 1729183 | COM |
| CONSTELLATION ENERGY CORP | 4812 | 1699935 | COM |
| META PLATFORMS INC | 2562 | 1691151 | CL A |
| APPLOVIN CORP | 2482 | 1672422 | COM CL A |
| MADRIGAL PHARMACEUTICALS INC | 2839 | 1653263 | COM |
| CELCUITY INC | 16543 | 1649999 | COM |
| LUMENTUM HLDGS INC | 4317 | 1591203 | COM |
| MASTERCARD INCORPORATED | 2784 | 1589330 | CL A |
| CLEVELAND-CLIFFS INC NEW | 118574 | 1574663 | COM |
| FERGUSON ENTERPRISES INC | 6973 | 1552399 | COMMON STOCK NEW |
| NEXTERA ENERGY INC | 19285 | 1548200 | COM |
| UNIFIRST CORP MASS | 7727 | 1490538 | COM |
| CLEAN HARBORS INC | 6243 | 1463859 | COM |
| EQT CORP | 27090 | 1452024 | COM |
| CELLDEX THERAPEUTICS INC NEW | 51805 | 1407024 | COM NEW |
| WORKDAY INC | 6486 | 1393063 | CL A |
| TREVI THERAPEUTICS INC | 106159 | 1329110 | COM |
| COMPASS THERAPEUTICS INC | 245532 | 1318507 | COM |
| THERMO FISHER SCIENTIFIC INC | 2269 | 1314772 | COM |
| TALEN ENERGY CORP | 3488 | 1307442 | COM |
| BOOKING HOLDINGS INC | 243 | 1301346 | COM |
| ORTHOFIX MED INC | 85049 | 1289343 | COM |
| ENLIVEN THERAPEUTICS INC | 82536 | 1271055 | COM |
| UNITY SOFTWARE INC | 28663 | 1266045 | COM |
| NEWAMSTERDAM PHARMA COMPANY | 35586 | 1248357 | ORDINARY SHARES |
| REDDIT INC | 5300 | 1218311 | CL A |
| CG ONCOLOGY INC | 29325 | 1217574 | COM |
| CIENA CORP | 5185 | 1212616 | COM NEW |
| RBC BEARINGS INC | 2703 | 1212106 | COM |
| KBR INC | 30006 | 1206241 | COM |
| INTUIT | 1813 | 1200968 | COM |
| API GROUP CORP | 30958 | 1184453 | COM STK |
| DYNE THERAPEUTICS INC | 59643 | 1166617 | COM |
| PURE STORAGE INC | 17409 | 1166577 | CL A |
| ACADIA HEALTHCARE COMPANY IN | 81630 | 1158329 | COM |
| GE VERNOVA INC | 1768 | 1155512 | COM |
| RXO INC | 90938 | 1149456 | COMMON STOCK |
| IMMUNOCORE HLDGS PLC | 32998 | 1145361 | ADS |
| UNITED THERAPEUTICS CORP DEL | 2330 | 1135293 | COM |
| QXO INC | 58720 | 1132709 | COM NEW |
| CENTESSA PHARMACEUTICALS PLC | 44490 | 1112695 | SPONSORED ADS |
| PTC INC | 6374 | 1110415 | COM |
| MASTEC INC | 5027 | 1092719 | COM |
| SCHWAB CHARLES CORP | 10601 | 1059146 | COM |
| NU HLDGS LTD | 62570 | 1047422 | ORD SHS CL A |
| SANDISK CORP | 4378 | 1039250 | COM |
| PENNYMAC FINL SVCS INC NEW | 7806 | 1029143 | COM |
| AFFIRM HLDGS INC | 13086 | 973991 | COM CL A |
| CORPORACION AMER ARPTS S A | 37145 | 965770 | COM |
| AMPHENOL CORP NEW | 7081 | 956926 | CL A |
| ENTERGY CORP NEW | 10328 | 954617 | COM |
| SEA LTD | 7450 | 950396 | SPONSORD ADS |
| FULL TRUCK ALLIANCE CO LTD | 87591 | 939851 | SPONSORED ADS |
| MERCADOLIBRE INC | 465 | 936631 | COM |
| CORE SCIENTIFIC INC NEW | 63512 | 924735 | COM |
| TYRA BIOSCIENCES INC | 35086 | 922411 | COM |
| VISTRA CORP | 5673 | 915225 | COM |
| CYTOMX THERAPEUTICS INC | 193941 | 826189 | COM |
| COMPANIA DE MINAS BUENAVENTU | 29649 | 825132 | SPONSORED ADR |
| SHIFT4 PMTS INC | 12982 | 817477 | CL A |
| HDFC BANK LTD | 22127 | 808521 | SPONSORED ADS |
| ICICI BANK LIMITED | 26284 | 783263 | ADR |
| ASCENDIS PHARMA A/S | 3660 | 780458 | SPONSORED ADR |
| TRIP COM GROUP LTD | 10646 | 765554 | ADS |
| ALKERMES PLC | 26401 | 738700 | SHS |
| GITLAB INC | 19305 | 724517 | CLASS A COM |
| NEW ORIENTAL ED & TECHNOLOGY | 12817 | 705320 | SPON ADR |
| ROBLOX CORP | 8431 | 683164 | CL A |
| ALCON AG | 10440 | 660643 | ORD SHS |
| UROGEN PHARMA LTD | 28005 | 655877 | COM |
| CNX RES CORP | 17624 | 648034 | COM |
| BANCO BRADESCO S A | 190264 | 633579 | SP ADR PFD NEW |
| 3M CO | 3950 | 632395 | COM |
| AUTOLIV INC | 5243 | 622344 | COM |
| PETROLEO BRASILEIRO SA PETRO | 55200 | 622104 | SP ADR NON VTG |
| XCEL ENERGY INC | 8058 | 595164 | COM |
| ARGAN INC | 1896 | 594055 | COM |
| COUPANG INC | 24792 | 584843 | CL A |
| JANUX THERAPEUTICS INC | 41443 | 571913 | COM |
| KYMERA THERAPEUTICS INC | 6835 | 531831 | COM |
| JD.COM INC | 17463 | 501189 | SPON ADS CL A |
| NEKTAR THERAPEUTICS | 11749 | 496748 | COM NEW |
| KANZHUN LIMITED | 20598 | 419787 | SPONSORED ADS |
| NOKIA CORP | 59524 | 385120 | SPONSORED ADR |
| DBV TECHNOLOGIES S A | 15877 | 304362 | SPONSORED ADS |
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