BAKER BROS. ADVISORS LP - Stock Holdings in 13F Filings (SEC)
Updated on March 15, 2026.
Based on 13F Filings filed with the SEC on February 17, 2026, for the 2025 Q4 period, BAKER BROS. ADVISORS LP held in its portfolio 85 assets valued at $17,078,624,105 (i.e. $17.08B).
The most valuable assets in the portfolio included: Incyte Corporation ($3.04B), BeOne Medicines Ltd. ($2.67B), and Madrigal Pharmaceuticals, Inc. ($1.25B).
The chart below shows the top 10 valuable assets, and the table below shows the top 85 valuable assets.
You can see similar for other investment managers.
Related Topics: SEC Topic List.
Data Source: SEC.
BAKER BROS. ADVISORS LP - Stock Holdings in 13F Filings (SEC)
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| Name of Issuer | No. of Shares | Value ($) | Class |
|---|---|---|---|
| Incyte Corporation | 30743991 | 3036583991 | COM |
| BeOne Medicines Ltd. | 8799053 | 2673240292 | SPONSORED ADS |
| Madrigal Pharmaceuticals, Inc. | 2141701 | 1247198160 | COM |
| Insmed Incorporated | 6592746 | 1147401514 | COM PAR $.01 |
| ACADIA Pharmaceuticals Inc. | 42896690 | 1145770590 | COM |
| Celcuity Inc. | 7915792 | 789521094 | COM |
| Revolution Medicines, Inc. | 9455357 | 753119185 | COM |
| Kymera Therapeutics, Inc. | 8657242 | 673620000 | COM |
| Summit Therapeutics Inc. | 36391063 | 636479692 | COM |
| Rhythm Pharmaceuticals, Inc. | 5604483 | 599903860 | COM |
| Kodiak Sciences Inc. | 19919186 | 556940441 | COM |
| Praxis Precision Medicines, Inc. | 1126488 | 332021073 | COM |
| Alkermes plc | 10012267 | 280143231 | SHS |
| GRAIL, Inc. | 2085333 | 178483651 | COM |
| Edgewise Therapeutics, Inc. | 6575940 | 163181951 | COM |
| Arrowhead Pharmaceuticals, Inc. | 2175645 | 144441072 | COM |
| Ionis Pharmaceuticals, Inc. | 1791841 | 141752542 | COM |
| Immunovant, Inc. | 5457881 | 138739335 | COM |
| Immatics N.V. | 12094094 | 126987987 | SHS |
| IDEAYA Biosciences, Inc. | 3618826 | 125102815 | COM |
| Roivant Sciences Ltd. | 5555017 | 120543869 | SHS |
| Abivax S.A. | 875796 | 118105470 | SPONSORED ADS |
| Kiniksa Pharmaceuticals International, plc | 2826246 | 116582648 | ORD SHS CL A |
| Replimune Group, Inc. | 11045336 | 107360666 | COM |
| Stoke Therapeutics, Inc. | 3336697 | 105906763 | COM |
| Structure Therapeutics Inc. | 1432529 | 99632392 | SPONSORED ADS |
| AbCellera Biologics Inc. | 27525640 | 94137689 | COM |
| Nurix Therapeutics, Inc. | 4658556 | 88372807 | COM |
| Immunocore Holdings plc | 2322656 | 80619390 | ADS |
| Bicycle Therapeutics plc | 10885357 | 77068328 | SPONSORED ADS |
| Crinetics Pharmaceuticals, Inc. | 1648869 | 76754852 | COM |
| Monte Rosa Therapeutics, Inc. | 4345736 | 68141140 | COM |
| Ultragenyx Pharmaceutical Inc. | 2772692 | 63771916 | COM |
| Denali Therapeutics Inc. | 3731695 | 61610284 | COM |
| Viridian Therapeutics, Inc. | 1971678 | 61358619 | COM |
| Entrada Therapeutics, Inc. | 5072730 | 52147664 | COM |
| Rapport Therapeutics, Inc. | 1547090 | 46938711 | COM |
| Terns Pharmaceuticals, Inc. | 950000 | 38380000 | COM |
| BioNTech SE | 368923 | 35121470 | SPONSORED ADS |
| Spyre Therapeutics, Inc. | 1000000 | 32760000 | COM |
| Dianthus Therapeutics, Inc. | 789759 | 32545968 | COM |
| Prelude Therapeutics Inc. | 10123824 | 29359090 | COM |
| DBV Technologies S.A. | 1461425 | 28015517 | SPONSORED ADS |
| Disc Medicine, Inc. | 337050 | 26765141 | COM |
| Jade Biosciences, Inc. | 1641137 | 25322744 | COM |
| Taysha Gene Therapies, Inc. | 4004756 | 22026158 | COM SHS |
| BioCryst Pharmaceuticals, Inc. | 2822727 | 22017271 | COM |
| Ventyx Biosciences, Inc. | 2349280 | 21213998 | COM |
| argenx SE | 25174 | 21170075 | SPONSORED ADR |
| Design Therapeutics, Inc. | 2233099 | 20946469 | COM |
| Cerus Corporation | 10008345 | 20617191 | COM |
| Neurogene Inc. | 991691 | 20428835 | COM |
| Tectonic Therapeutic, Inc. | 903400 | 18844924 | COM |
| CytomX Therapeutics, Inc. | 4250826 | 18108519 | COM |
| Celldex Therapeutics, Inc. | 665370 | 18071449 | COM |
| Xencor, Inc. | 1102106 | 16873243 | COM |
| Centessa Pharmaceuticals plc | 670751 | 16775483 | SPONSORED ADS |
| Xenon Pharmaceuticals Inc. | 370208 | 16592723 | COM |
| Sionna Therapeutics, Inc. | 400000 | 16456000 | COM |
| Contineum Therapeutics, Inc. | 1420838 | 16240178 | CL A |
| Sera Prognostics, Inc. | 5498170 | 16219602 | CLASS A COM |
| Dyne Therapeutics, Inc. | 813449 | 15911062 | COM |
| Alumis Inc. | 1562500 | 15250000 | COM |
| Nuvalent, Inc. | 143937 | 14478623 | COM |
| Pharvaris N.V. | 375000 | 10406250 | COM |
| Relay Therapeutics, Inc. | 1160117 | 9814590 | COM |
| Absci Corporation | 2134803 | 7450462 | COM |
| Arcus Biosciences, Inc. | 270000 | 6434100 | COM |
| MapLight Therapeutics, Inc. | 364705 | 6406043 | COM |
| vTv Therapeutics, Inc. | 148314 | 5931077 | CL A |
| Wave Life Sciences Ltd. | 344063 | 5849071 | SHS |
| Sagimet Biosciences Inc. | 952996 | 5641736 | COM SER A |
| Protara Therapeutics, Inc. | 971614 | 5178703 | COM STK |
| LB Pharmaceuticals Inc. | 200000 | 4452000 | COM SHS |
| Enliven Therapeutics, Inc. | 271406 | 4179652 | COM |
| 4D Molecular Therapeutics, Inc. | 475737 | 3568028 | COM |
| Vir Biotechnology, Inc. | 542539 | 3271510 | COM |
| TScan Therapeutics, Inc. | 2784792 | 2784792 | COM |
| Sana Biotechnology, Inc. | 310483 | 1263666 | COM |
| Skye Bioscience, Inc. | 1450638 | 1087543 | COM |
| KALA BIO, Inc. | 1804055 | 1002874 | COM |
| Aligos Therapeutics, Inc. | 83055 | 774073 | COM |
| Tyra Biosciences, Inc. | 10607 | 278858 | COM |
| Acrivon Therapeutics, Inc. | 22809 | 54970 | COMMON STOCK |
| Surrozen, Inc. | 833333 | 16667 | W EXP 8/11/2026 |
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